Aligning to the sample-specific reference sequence to optimize the accuracy of next-generation sequencing analysis for hepatitis B virus

BACKGROUND: Hepatitis B virus (HBV) quasispecies are crucial in the pathogenesis of chronic liver disease. Next-generation sequencing (NGS) is powerful for identifying viral quasispecies. To improve mapping quality and single nucleotide variant (SNV) calling accuracy in the NGS analysis of HBV, we c...

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Detalhes bibliográficos
Publicado no:Hepatol Int
Main Authors: Liu, Wen-Chun, Lin, Chih-Peng, Cheng, Chun-Pei, Ho, Cheng-Hsun, Lan, Kuo-Lun, Cheng, Ji-Hong, Yen, Chia-Jui, Cheng, Pin-Nan, Wu, I-Chin, Li, I-Chen, Chang, Bill Chia-Han, Tseng, Vincent S., Chiu, Yen-Cheng, Chang, Ting-Tsung
Formato: Artigo
Idioma:Inglês
Publicado em: Springer India 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722079/
https://ncbi.nlm.nih.gov/pubmed/26208819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12072-015-9645-x
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