Cyclophilin40 isomerase activity is regulated by a temperature-dependent allosteric interaction with Hsp90

Cyclophilin 40 (Cyp40) comprises an N-terminal cyclophilin domain with peptidyl-prolyl isomerase (PPIase) activity and a C-terminal tetratricopeptide repeat (TPR) domain that binds to the C-terminal–EEVD sequence common to both heat shock protein 70 (Hsp70) and Hsp90. We show in the present study th...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Blackburn, Elizabeth A., Wear, Martin A., Landré, Vivian, Narayan, Vikram, Ning, Jia, Erman, Burak, Ball, Kathryn L., Walkinshaw, Malcolm D.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2015
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721547/
https://ncbi.nlm.nih.gov/pubmed/26330616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150124
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