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Domain cooperativity in multidomain proteins: what can we learn from molecular alignment in anisotropic media?
Many proteins have modular design with multiple globular domains connected via flexible linkers. As a simple model of such system, we study a tandem construct consisting of two identical SH3 domains and a variable-length Gly/Ser linker. When the linker is short, this construct represents a dumbbell-...
Enregistré dans:
| Publié dans: | J Biomol NMR |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4721247/ https://ncbi.nlm.nih.gov/pubmed/21947922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-011-9548-7 |
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