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Amylin-Aβ oligomers at atomic resolution using molecular dynamics simulations: a link between Type 2 diabetes and Alzheimer's disease

Clinical studies identified Type 2 diabetes (T2D) as a risk factor of Alzheimer's disease (AD). One of the potential mechanisms that link T2D and AD is the loss of cells associated with degenerative changes. Amylin(1-37) aggregates (the pathological species in T2D) were found to be co-localized...

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Detalhes bibliográficos
Publicado no:Phys Chem Chem Phys
Main Authors: Baram, Michal, Atsmon-Raz, Yoav, Ma, Buyong, Nussinov, Ruth, Miller, Yifat
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720542/
https://ncbi.nlm.nih.gov/pubmed/26349542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cp03338a
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