Transcription factor trapping by RNA in gene regulatory elements

Transcription factors (TFs) bind specific sequences in promoter-proximal and distal DNA elements in order to regulate gene transcription. RNA is transcribed from both of these DNA elements, and some DNA-binding TFs bind RNA. Hence, RNA transcribed from regulatory elements may contribute to stable TF...

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Vydáno v:Science
Hlavní autoři: Sigova, Alla A., Abraham, Brian J., Ji, Xiong, Molinie, Benoit, Hannett, Nancy M., Eric Guo, Yang, Jangi, Mohini, Giallourakis, Cosmas C., Sharp, Phillip A., Young, Richard A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720525/
https://ncbi.nlm.nih.gov/pubmed/26516199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3346
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