Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis

Silicosis is an occupational lung disease with no effective treatment. We hypothesized that dasatinib, a tyrosine kinase inhibitor, might exhibit therapeutic efficacy in silica-induced pulmonary fibrosis. Silicosis was induced in C57BL/6 mice by a single intratracheal administration of silica partic...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cruz, Fernanda Ferreira, Horta, Lucas Felipe Bastos, Maia, Lígia de Albuquerque, Lopes-Pacheco, Miquéias, da Silva, André Benedito, Morales, Marcelo Marco, Gonçalves-de-Albuquerque, Cassiano Felippe, Takiya, Christina Maeda, de Castro-Faria-Neto, Hugo Caire, Rocco, Patricia Rieken Macedo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720427/
https://ncbi.nlm.nih.gov/pubmed/26789403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147005
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