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Preventing Cleavage of the Respiratory Syncytial Virus Attachment Protein in Vero Cells Rescues the Infectivity of Progeny Virus for Primary Human Airway Cultures

All live attenuated respiratory syncytial virus (RSV) vaccines that have advanced to clinical trials have been produced in Vero cells. The attachment (G) glycoprotein in virions produced in these cells is smaller than that produced in other immortalized cells due to cleavage. These virions are 5-fol...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Corry, Jacqueline, Johnson, Sara M., Cornwell, Jessica, Peeples, Mark E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719620/
https://ncbi.nlm.nih.gov/pubmed/26581976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02351-15
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