Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation

Angiogenesis is a central regulator for white (WAT) and brown (BAT) adipose tissue adaptation in the course of obesity. Here we show that deletion of hypoxia-inducible factor 2α (HIF2α) in adipocytes (by using Fabp4-Cre transgenic mice) but not in myeloid or endothelial cells negatively impacted WAT...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: García-Martín, Rubén, Alexaki, Vasileia I., Qin, Nan, Rubín de Celis, María F., Economopoulou, Matina, Ziogas, Athanasios, Gercken, Bettina, Kotlabova, Klara, Phieler, Julia, Ehrhart-Bornstein, Monika, Bornstein, Stefan R., Eisenhofer, Graeme, Breier, Georg, Blüher, Matthias, Hampe, Jochen, El-Armouche, Ali, Chatzigeorgiou, Antonios, Chung, Kyoung-Jin, Chavakis, Triantafyllos
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719429/
https://ncbi.nlm.nih.gov/pubmed/26572826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00430-15
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