T cells from patients with Candida sepsis display a suppressive immunophenotype

BACKGROUND: Despite appropriate therapy, Candida bloodstream infections are associated with a mortality rate of approximately 40 %. In animal models, impaired immunity due to T cell exhaustion has been implicated in fungal sepsis mortality. The purpose of this study was to determine potential mechan...

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Dettagli Bibliografici
Pubblicato in:Crit Care
Autori principali: Spec, Andrej, Shindo, Yuichiro, Burnham, Carey-Ann D., Wilson, Strother, Ablordeppey, Enyo A., Beiter, Evan R., Chang, Katherine, Drewry, Anne M., Hotchkiss, Richard S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719210/
https://ncbi.nlm.nih.gov/pubmed/26786705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-016-1182-z
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