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Complementing reversed-phase selectivity with porous graphitized carbon to increase the metabolome coverage in an on-line two-dimensional LC-MS setup for metabolomics

Efficient and robust separation methods are indispensable in modern LC-MS based metabolomics, where high-resolution mass spectrometers are challenged by isomeric and isobaric metabolites. The optimization of chromatographic separation hence remains an invaluable tool in the comprehensive analysis of...

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Detalhes bibliográficos
Publicado no:Analyst
Main Authors: Ortmayr, Karin, Hann, Stephan, Koellensperger, Gunda
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719141/
https://ncbi.nlm.nih.gov/pubmed/25824707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5an00206k
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