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Canonical Notch activation in osteocytes causes osteopetrosis
Activation of Notch1 in cells of the osteoblastic lineage inhibits osteoblast differentiation/function and causes osteopenia, whereas its activation in osteocytes causes a distinct osteopetrotic phenotype. To explore mechanisms responsible, we established the contributions of canonical Notch signali...
Gardado en:
| Publicado en: | Am J Physiol Endocrinol Metab |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Physiological Society
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4719030/ https://ncbi.nlm.nih.gov/pubmed/26578715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00395.2015 |
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