Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes.

Transgenic mice were generated using a purified 248-kb yeast artificial chromosome (YAC) bearing an intact 82-kb human beta-globin locus and 148 kb of flanking sequence. Seventeen of 148 F0 pups were transgenic. RNase protection analysis of RNA isolated from the blood of 13 gamma- and beta-globin-po...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Peterson, K R, Clegg, C H, Huxley, C, Josephson, B M, Haugen, H S, Furukawa, T, Stamatoyannopoulos, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47188/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8356061/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.16.7593
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