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Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi)
Haploinsufficiency for the Notch ligand JAG1 in humans results in an autosomal dominant, multisystem disorder known as Alagille syndrome, which is characterized by a congenital cholangiopathy of variable severity. Here we show that on a C57BL/6 background, jagged1 heterozygous mice (Jag1(+/−)) exhib...
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| Publicado en: | Hepatology |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718747/ https://ncbi.nlm.nih.gov/pubmed/26235536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28024 |
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