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Over-activation of the Nrf2-Antioxidant Response Element Pathway in Hepatocytes Decreases Hepatic Ischemia Reperfusion Injury in Mice

BACKGROUND AND AIMS: Hepatic ischemia reperfusion injury (IRI) is a critical component of hepatic surgery. Oxidative stress has long been implicated as a key player in IRI. In this study, we examine the cell-specific role of the Nrf2-antioxidant response element pathway in warm hepatic IRI. METHODS:...

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Publicat a:Liver Transpl
Autors principals: Lee, Lung-Yi, Harberg, Calvin, Matkowskyj, Kristina A., Cook, Shelly, Roenneburg, Drew, Werner, Sabine, Johnson, Jeffrey, Foley, David P.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718744/
https://ncbi.nlm.nih.gov/pubmed/26285140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lt.24303
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