In vitro eradication of citrullinated protein specific B-lymphocytes of rheumatoid arthritis patients by targeted bifunctional nanoparticles

BACKGROUND: Autoreactive B cells are crucial players in the pathogenesis of rheumatoid arthritis (RA). Autoantibodies specific for citrullinated proteins (ACPA), present in the serum of approximately 60–70 % of patients, have a pathogenic role in the disease. B cell depleting therapies may result in...

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Библиографические подробности
Опубликовано в: :Arthritis Res Ther
Главные авторы: Pozsgay, Judit, Babos, Fruzsina, Uray, Katalin, Magyar, Anna, Gyulai, Gergő, Kiss, Éva, Nagy, György, Rojkovich, Bernadette, Hudecz, Ferenc, Sármay, Gabriella
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718042/
https://ncbi.nlm.nih.gov/pubmed/26780830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0918-0
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