Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1

BACKGROUND: Rheumatoid arthritis fibroblast-like synovial cells (RA-FLS) show resistance to methotrexate (MTX) treatment. To better understand the mechanisms of this resistance, RA-FLS and osteoarthritis fibroblast-like synovial cells (OA-FLS) were isolated and exposed to MTX. We analyzed the autoph...

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Publicat a:Arthritis Res Ther
Autors principals: Xu, Ke, Cai, Yong-song, Lu, She-Min, Li, Xiao-li, Liu, Lin, Li, Zhong, Liu, Hui, Xu, Peng
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718027/
https://ncbi.nlm.nih.gov/pubmed/26702616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0892-y
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