Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer

BACKGROUND: Amplifications of the transcription factor, SRY (sex determining region Y)-box 2 (SOX2), are common in non-small cell lung cancer (NSCLC). SOX2 signaling is important in maintaining the stem cell-like phenotype of cancer cells and contributes to the pathogenesis of lung cancer. TP53 is k...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Samulin Erdem, Johanna, Skaug, Vidar, Bakke, Per, Gulsvik, Amund, Haugen, Aage, Zienolddiny, Shanbeh
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717590/
https://ncbi.nlm.nih.gov/pubmed/26780934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2061-3
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