The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression

OBJECTIVES: To evaluate efficacy and safety of combination therapy using certolizumab pegol (CZP) and methotrexate (MTX) as first-line treatment for MTX-naive, early rheumatoid arthritis (RA) with poor prognostic factors, compared with MTX alone. METHODS: MTX-naive, early RA patients with ≤12 months...

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Bibliographic Details
Published in:Ann Rheum Dis
Main Authors: Atsumi, Tatsuya, Yamamoto, Kazuhiko, Takeuchi, Tsutomu, Yamanaka, Hisashi, Ishiguro, Naoki, Tanaka, Yoshiya, Eguchi, Katsumi, Watanabe, Akira, Origasa, Hideki, Yasuda, Shinsuke, Yamanishi, Yuji, Kita, Yasuhiko, Matsubara, Tsukasa, Iwamoto, Masahiro, Shoji, Toshiharu, Okada, Toshiyuki, van der Heijde, Désirée, Miyasaka, Nobuyuki, Koike, Takao
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2016
Subjects:
Clinical and Epidemiological Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717398/
https://ncbi.nlm.nih.gov/pubmed/26139005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-207511
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