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Extracellular 2′5′‐oligoadenylate synthetase 2 mediates T‐cell receptor CD3‐ζ chain down‐regulation via caspase‐3 activation in oral cancer

Decreased expression of CD3‐ζ chain, an adaptor protein associated with T‐cell signalling, is well documented in patients with oral cancer, but the mechanistic justifications are fragmentary. Previous studies in patients with oral cancer have shown that decreased expression of CD3‐ζ chain was associ...

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Detalhes bibliográficos
Publicado no:Immunology
Main Authors: Dar, Asif A., Pradhan, Trupti N., Kulkarni, Dakshayni P., Shah, Sagar U., Rao, Kanury V., Chaukar, Devendra A., D'Cruz, Anil K., Chiplunkar, Shubhada V.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717238/
https://ncbi.nlm.nih.gov/pubmed/26595239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12560
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