Sustained Release of Triamcinolone Acetonide from an Intratympanically Applied Hydrogel Designed for the Delivery of High Glucocorticoid Doses

The pharmacokinetic properties and tolerability of a triamcinolone acetonide poloxamer 407 hydrogel for intratympanic application were investigated in a guinea pig model. Evaluation of in vivo release kinetics showed very high initial perilymph drug levels, with clinically relevant levels present fo...

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Vydáno v:Audiol Neurootol
Hlavní autoři: Honeder, Clemens, Engleder, Elisabeth, Schöpper, Hanna, Gabor, Franz, Reznicek, Gottfried, Wagenblast, Jens, Gstoettner, Wolfgang, Arnoldner, Christoph
Médium: Artigo
Jazyk:Inglês
Vydáno: S. Karger AG 2014
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717230/
https://ncbi.nlm.nih.gov/pubmed/24714604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000358165
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