Influence of ADME genomic variants on tacrolimus/sirolimus blood levels and GVHD after allogeneic hematopoietic cell transplantation

Allelic variants of genes implicated in drug absorption, distribution, metabolism, and excretion (ADME) determine the pharmacokinetic variability of many medications and are increasingly recognized as important factors determining the success or failure of medical treatments. Both tacrolimus and sir...

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Publicado en:Biol Blood Marrow Transplant
Autores principales: Khaled, Samer K., Palmer, Joycelynne M., Herzog, Josef, Stiller, Tracey, Tsai, Ni-Chun, Senitzer, David, Liu, Xueli, Thomas, Sandra H., Shayani, Sepideh, Weitzel, Jeffrey, Forman, Stephen J., Nakamura, Ryotaro
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716887/
https://ncbi.nlm.nih.gov/pubmed/26325438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2015.08.027
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