Influence of ADME genomic variants on tacrolimus/sirolimus blood levels and GVHD after allogeneic hematopoietic cell transplantation

Allelic variants of genes implicated in drug absorption, distribution, metabolism, and excretion (ADME) determine the pharmacokinetic variability of many medications and are increasingly recognized as important factors determining the success or failure of medical treatments. Both tacrolimus and sir...

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Détails bibliographiques
Publié dans:Biol Blood Marrow Transplant
Auteurs principaux: Khaled, Samer K., Palmer, Joycelynne M., Herzog, Josef, Stiller, Tracey, Tsai, Ni-Chun, Senitzer, David, Liu, Xueli, Thomas, Sandra H., Shayani, Sepideh, Weitzel, Jeffrey, Forman, Stephen J., Nakamura, Ryotaro
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716887/
https://ncbi.nlm.nih.gov/pubmed/26325438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2015.08.027
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