Mechanism and treatment for the learning and memory deficits associated with mouse models of Noonan syndrome

In Noonan Syndrome (NS) 30% to 50% of subjects show cognitive deficits of unknown etiology and with no known treatment. Here, we report that knock-in mice expressing either of two NS-associated Ptpn11 mutations show hippocampal-dependent spatial learning impairments and deficits in hippocampal long-...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Lee, Yong-Seok, Ehninger, Dan, Zhou, Miou, Oh, Jun-Young, Kang, Minkyung, Kwak, Chuljung, Ryu, Hyun-Hee, Butz, Delana, Araki, Toshiyuki, Cai, Ying, Balaji, J., Sano, Yoshitake, Nam, Christine I., Kim, Hyong Kyu, Kaang, Bong-Kiun, Burger, Corinna, Neel, Benjamin G., Silva, Alcino J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716736/
https://ncbi.nlm.nih.gov/pubmed/25383899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3863
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