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Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin
Nucleosome positioning varies between cell types. By deep sequencing cell-free DNA (cfDNA) isolated from circulating blood plasma, we generated maps of genome-wide in vivo nucleosome occupancy, and found that short cfDNA fragments harbor footprints of transcription factors. The cfDNA nucleosome occu...
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| Publicado no: | Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4715266/ https://ncbi.nlm.nih.gov/pubmed/26771485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.11.050 |
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