The Hydroxyl at Position C1 of Genipin Is the Active Inhibitory Group that Affects Mitochondrial Uncoupling Protein 2 in Panc-1 Cells

Genipin (GNP) effectively inhibits uncoupling protein 2 (UCP2), which regulates the leakage of protons across the inner mitochondrial membrane. UCP2 inhibition may induce pancreatic adenocarcinoma cell death by increasing reactive oxygen species (ROS) levels. In this study, the hydroxyls at position...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Yang, Yang, Yang, Yifu, Hou, Jianwei, Ding, Yue, Zhang, Tong, Zhang, Yong, Wang, Jianying, Shi, Chenchen, Fu, Wenwei, Cai, Zhenzhen
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714807/
https://ncbi.nlm.nih.gov/pubmed/26771380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147026
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