Panobinostat PK/PD profile in combination with bortezomib and dexamethasone in patients with relapsed and relapsed/refractory multiple myeloma

PURPOSE: Panobinostat, a potent pan-deacetylase inhibitor, improved progression-free survival (PFS) in patients with relapsed and refractory multiple myeloma when combined with bortezomib and dexamethasone in a phase 3 trial, PANORAMA-1. This study aims to explore exposure–response relationship for...

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Dettagli Bibliografici
Pubblicato in:Eur J Clin Pharmacol
Autori principali: Mu, Song, Kuroda, Yoshiaki, Shibayama, Hirohiko, Hino, Masayuki, Tajima, Takeshi, Corrado, Claudia, Lin, Rong, Waldron, Edward, Binlich, Florence, Suzuki, Kenshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2015
Soggetti:
Clinical Trial
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713719/
https://ncbi.nlm.nih.gov/pubmed/26494130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-015-1967-z
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