Dual Endothelin Receptor Blockade Abrogates Right Ventricular Remodeling and Biventricular Fibrosis in Isolated Elevated Right Ventricular Afterload

BACKGROUND: Pulmonary arterial hypertension is usually fatal due to right ventricular failure and is frequently associated with co-existing left ventricular dysfunction. Endothelin-1 is a powerful pro-fibrotic mediator and vasoconstrictor that is elevated in pulmonary arterial hypertension. Endothel...

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Bibliographic Details
Published in:PLoS One
Main Authors: Nielsen, Eva Amalie, Sun, Mei, Honjo, Osami, Hjortdal, Vibeke E., Redington, Andrew N., Friedberg, Mark K.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713098/
https://ncbi.nlm.nih.gov/pubmed/26765263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146767
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