A Method to Quantify Cell-Free Fetal DNA Fraction in Maternal Plasma Using Next Generation Sequencing: Its Application in Non-Invasive Prenatal Chromosomal Aneuploidy Detection

OBJECTIVE: The fraction of circulating cell-free fetal (cff) DNA in maternal plasma is a critical parameter for aneuploidy screening with non-invasive prenatal testing, especially for those samples located in equivocal zones. We developed an approach to quantify cff DNA fractions directly with seque...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Xu, Xu-Ping, Gan, Hai-Yan, Li, Fen-Xia, Tian, Qi, Zhang, Jun, Liang, Rong-Liang, Li, Ming, Yang, Xue-Xi, Wu, Ying-Song
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713075/
https://ncbi.nlm.nih.gov/pubmed/26765738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146997
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