Acquisition of Estrogen Independence Induces TOB1-Related Mechanisms Supporting Breast Cancer Cell Proliferation

Resistance to therapies targeting the estrogen pathway remains a challenge in the treatment of estrogen-receptor positive breast cancer. To address this challenge, a systems biology approach was used. A library of siRNAs targeting an estrogen receptor- and aromatase-centered network identified 46 ge...

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Bibliographic Details
Published in:Oncogene
Main Authors: Zhang, Yong-Wei, Nasto, Rochelle E., Varghese, Rency, Jablonski, Sandra A., Serebriiskii, Ilya G, Surana, Rishi, Calvert, Valerie S., Bebu, Ionut, Murray, Joseph, Jin, Lu, Johnson, Michael, Riggins, Rebecca, Ressom, Habtom, Petricoin, Emmanuel, Clarke, Robert, Golemis, Erica A., Weiner, Louis M.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712124/
https://ncbi.nlm.nih.gov/pubmed/26165839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.226
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