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Steroidogenic Factor 1 Differentially Regulates Fetal and Adult Leydig Cell Development in Male Mice

The nuclear receptor steroidogenic factor 1 (SF-1, AD4BP, NR5A1) is a key regulator of the endocrine axes and is essential for adrenal and gonad development. Partial rescue of Nr5a1(−/−) mice with an SF-1-expressing transgene caused a hypomorphic phenotype that revealed its roles in Leydig cell deve...

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Detalhes bibliográficos
Publicado no:Biol Reprod
Main Authors: Karpova, Tatiana, Ravichandiran, Kumarasamy, Insisienmay, Lovella, Rice, Daren, Agbor, Valentine, Heckert, Leslie L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for the Study of Reproduction, Inc. 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711904/
https://ncbi.nlm.nih.gov/pubmed/26269506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.115.131193
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