Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies

Despite progress in systemic small interfering RNA (siRNA) delivery to the liver and to solid tumors, systemic siRNA delivery to leukocytes remains challenging. The ability to silence gene expression in leukocytes has great potential for identifying drug targets and for RNAi-based therapy for leukoc...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Weinstein, Shiri, Toker, Itai A., Emmanuel, Rafi, Ramishetti, Srinivas, Hazan-Halevy, Inbal, Rosenblum, Daniel, Goldsmith, Meir, Abraham, Avigdor, Benjamini, Ohad, Bairey, Osnat, Raanani, Pia, Nagler, Arnon, Lieberman, Judy, Peer, Dan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711827/
https://ncbi.nlm.nih.gov/pubmed/26699502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519273113
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