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The IgLON Family Member Negr1 Promotes Neuronal Arborization Acting as Soluble Factor via FGFR2

IgLON proteins are GPI anchored adhesion molecules that control neurite outgrowth. In particular, Negr1 down-regulation negatively influences neuronal arborization in vitro and in vivo. In the present study, we found that the metalloprotease ADAM10 releases Negr1 from neuronal membrane. Ectodomain s...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Pischedda, Francesca, Piccoli, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710852/
https://ncbi.nlm.nih.gov/pubmed/26793057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2015.00089
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