Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy

Generalized spike-wave seizures involving abnormal synchronization of cortical and underlying thalamic circuitry represent a major category of childhood epilepsy. Inborn errors of Cacna1a, the P/Q-type voltage-gated calcium channel α subunit gene, expressed throughout the brain destabilize corticoth...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Bomben, Valerie C., Aiba, Isamu, Qian, Jing, Mark, Melanie D., Herlitze, Stefan, Noebels, Jeffrey L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2016
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710767/
https://ncbi.nlm.nih.gov/pubmed/26758833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2555-15.2016
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