Impact Study: MK-0646 (Dalotuzumab), Insulin Growth Factor 1 Receptor Antibody Combined with Pemetrexed and Cisplatin in Stage IV Metastatic Non-squamous Lung Cancer

BACKGROUND: Insulin-like growth factor 1 receptor (IGF-1R) regulates cell growth, proliferation, and apoptosis. Adenocarcinoma and never-smokers have a higher expression of IGF-1R, which is associated with worse overall survival. Dalotuzumab-MK0646 (D) is a humanized monoclonal antibody that targets...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Huang, Chao H., Williamson, Stephen K., Neupane, Prakash, Taylor, Sarah A., Allen, Ace, Smart, Nora J., Uypeckcuat, Adelina M., Spencer, Sarah, Wick, Jo, Smith, Holly, Van Veldhuizen, Peter J., Kelly, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710681/
https://ncbi.nlm.nih.gov/pubmed/26793618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2015.00301
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