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New Blocking Antibodies against Novel AGR2-C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice
Anterior gradient 2 (AGR2) promotes cancer growth, metastasis and resistance to therapy via unknown mechanisms. We investigated the effects of extracellular AGR2 signaling through the orphan GPI-linked receptor C4.4A in pancreatic ductal adenocarcinoma (PDAC). Proliferation, migration and invasion a...
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| Veröffentlicht in: | Mol Cancer Ther |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4710371/ https://ncbi.nlm.nih.gov/pubmed/25646014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0470 |
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