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Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter
O-glycosylation of the nuclear pore complex (NPC) by O-linked N-acetylglucosamine (O-GlcNAc) is conserved within metazoans. Many nucleoporins (Nups) comprising the NPC are constitutively O-GlcNAcylated, but the functional role of this modification remains enigmatic. We show that loss of O-GlcNAc, in...
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| Publicado no: | J Mol Cell Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4710208/ https://ncbi.nlm.nih.gov/pubmed/26031751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjv033 |
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