Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 ≥ 1,000 U/mL

Patients with pancreatic ductal adenocarcinoma (PDAC) and preoperative CA19-9 ≥ 1,000 U/mL that does not decrease postresection have the worst prognosis, but the mechanism is unclear. Here, we elucidated the relationship between this signature and driver-gene mutations, and the cavins/caveolin-1 axi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Xiang, Jin-Feng, Wang, Wen-Quan, Liu, Liang, Xu, Hua-Xiang, Wu, Chun-Tao, Yang, Jing-Xuan, Qi, Zi-Hao, Wang, Ya-Qi, Xu, Jin, Liu, Chen, Long, Jiang, Ni, Quan-Xing, Li, Min, Yu, Xian-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709775/
https://ncbi.nlm.nih.gov/pubmed/26753987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19222
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