Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum) are refractory to EBOV infection. This could...

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Udgivet i:eLife
Main Authors: Ng, Melinda, Ndungo, Esther, Kaczmarek, Maria E, Herbert, Andrew S, Binger, Tabea, Kuehne, Ana I, Jangra, Rohit K, Hawkins, John A, Gifford, Robert J, Biswas, Rohan, Demogines, Ann, James, Rebekah M, Yu, Meng, Brummelkamp, Thijn R, Drosten, Christian, Wang, Lin-Fa, Kuhn, Jens H, Müller, Marcel A, Dye, John M, Sawyer, Sara L, Chandran, Kartik
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2015
Fag:
Genomics and Evolutionary Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709267/
https://ncbi.nlm.nih.gov/pubmed/26698106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11785
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