An erythromycin analog produced by reprogramming of polyketide synthesis.
The polyketide-derived macrolactone of the antibiotic erythromycin is made through successive condensation and processing of seven three-carbon units. The fourth cycle involves complete processing of the newly formed beta-keto group (beta-keto reduction, dehydration, and enoyl reduction) to yield th...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1993
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47087/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8346223/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.15.7119 |
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