Intracoronary Transplantation of Mesenchymal Stem Cells with Overexpressed Integrin-Linked Kinase Improves Cardiac Function in Porcine Myocardial Infarction

The effect of mesenchymal stem cell (MSCs)-based therapy on treating acute myocardial infarction (MI) is limited due to poor engraftment and limited regenerative potential. Here we engineered MSCs with integrin-linked kinase (ILK), a pleiotropic protein critically regulating cell survival, prolifera...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Mu, Dan, Zhang, Xin-Lin, Xie, Jun, Yuan, Hui-Hua, Wang, Kun, Huang, Wei, Li, Guan-Nan, Lu, Jian-Rong, Mao, Li-Juan, Wang, Lian, Cheng, Le, Mai, Xiao-Li, Yang, Jun, Tian, Chuan-Shuai, Kang, Li-Na, Gu, Rong, Zhu, Bin, Xu, Biao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707493/
https://ncbi.nlm.nih.gov/pubmed/26750752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19155
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