A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5

The presence of neutralizing epitopes in human papillomavirus (HPV) L1 virus-like particles (VLPs) is the structural basis of prophylactic vaccines. An anti-HPV16 neutralizing monoclonal antibody (N-mAb) 26D1 was isolated from a memory B cell of a human vaccinee. The pre-binding of heparan sulfate t...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Xia, Lin, Xian, Yangfei, Wang, Daning, Chen, Yuanzhi, Huang, Xiaofen, Bi, Xingjian, Yu, Hai, Fu, Zheng, Liu, Xinlin, Li, Shaowei, An, Zhiqiang, Luo, Wenxin, Zhao, Qinjian, Xia, Ningshao
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707464/
https://ncbi.nlm.nih.gov/pubmed/26750243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19042
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