Targeting YAP-dependent MDSC infiltration impairs tumor progression

The signaling mechanisms between prostate cancer cells and infiltrating immune cells may illuminate novel therapeutic approaches. Here, utilizing a prostate adenocarcinoma model driven by loss of Pten and Smad4, we identify polymorphonuclear myeloid-derived suppressor cells (MDSCs) as the major infi...

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Publicat a:Cancer Discov
Autors principals: Wang, Guocan, Lu, Xin, Dey, Prasenjit, Deng, Pingna, Wu, Chia Chin, Jiang, Shan, Fang, Zhuangna, Zhao, Kun, Konaparthi, Ramakrishna, Hua, Sujun, Zhang, Jianhua, Li-Ning-Tapia, Elsa M., Kapoor, Avnish, Wu, Chang-Jiun, Patel, Neelay Bhaskar, Guo, Zhenglin, Ramamoorthy, Vandhana, Tieu, Trang N., Heffernan, Tim, Zhao, Di, Shang, Xiaoying, Khadka, Sunada, Hou, Pingping, Hu, Baoli, Jin, Eun-Jung, Yao, Wantong, Pan, Xiaolu, Ding, Zhihu, Shi, Yanxia, Li, Liren, Chang, Qing, Troncoso, Patricia, Logothetis, Christopher J., McArthur, Mark J., Chin, Lynda, Wang, Y. Alan, DePinho, Ronald A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707102/
https://ncbi.nlm.nih.gov/pubmed/26701088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0224
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