Conformational Selection in a Protein-Protein Interaction revealed by Dynamic Pathway Analysis

Molecular recognition plays a central role in biology, and protein dynamics has been acknowledged to be important in this process. However, it is highly debated whether conformational changes happen before ligand binding to produce a binding-competent state (conformational selection) or are caused i...

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Publicado no:Cell Rep
Main Authors: Chakrabarti, Kalyan S., Agafonov, Roman V., Pontiggia, Francesco, Otten, Renee, Higgins, Matthew K., Schertler, Gebhard F. X., Oprian, Daniel D., Kern, Dorothee
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706811/
https://ncbi.nlm.nih.gov/pubmed/26725117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.010
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