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Piperlongumine for enhancing oral bioavailability and cytotoxicity of docetaxel in triple negative breast cancer

Very low oral bioavailability due to extensive pre-systemic metabolism and P-gp efflux has constrained the oral metronomic chemotherapy of docetaxel (DTX). There is tremendous need of compounds facilitating oral delivery of DTX. The research was aimed to investigate the effect of piperlongumine (PPL...

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Publicat a:J Pharm Sci
Autors principals: Patel, Ketan, Chowdhury, Nusrat, Doddapaneni, Ravi, Boakye, Cedar H. A., Singh, Mandip
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706797/
https://ncbi.nlm.nih.gov/pubmed/26372815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24637
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