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Characterization of the domain orientations of E. coli 5’-nucleotidase by fitting an ensemble of conformers to DEER distance distributions

Escherichia coli 5’-nucleotidase is a two-domain enzyme exhibiting a unique 96° domain motion that is required for catalysis. Here we present an integrated structural biology study that combines DEER distance distributions with structural information from X-ray crystallography and computational biol...

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Bibliografski detalji
Izdano u:Structure
Glavni autori: Krug, Ulrike, Alexander, Nathan S., Stein, Richard A., Keim, Antje, Mchaourab, Hassane S., Sträter, Norbert, Meiler, Jens
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706771/
https://ncbi.nlm.nih.gov/pubmed/26724996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.11.007
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