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Direct lineage reprogramming reveals disease-specific phonotypes of motor neurons from human ALS patients

Subtype-specific neurons obtained from adult humans will be critical to modeling neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). Here we show that adult human skin fibroblasts can be directly and efficiently converted into highly pure motor neurons without passing through an...

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Publicat a:Cell Rep
Autors principals: Liu, Meng-Lu, Zang, Tong, Zhang, Chun-Li
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706770/
https://ncbi.nlm.nih.gov/pubmed/26725112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.018
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