A defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs

The high-affinity reductive iron uptake system that includes a ferroxidase (Cfo1) and an iron permease (Cft1) is critical for the pathogenesis of Cryptococcus neoformans. In addition, a mutant lacking CFO1 or CFT1 not only has reduced iron uptake but also displays a markedly increased susceptibility...

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Vydáno v:Fungal Genet Biol
Hlavní autoři: Kim, Jeongmi, Cho, Yong-Joon, Do, Eunsoo, Choi, Jaehyuk, Hu, Guanggan, Cadieux, Brigitte, Chun, Jongsik, Lee, Younghoon, Kronstad, James W., Jung, Won Hee
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706552/
https://ncbi.nlm.nih.gov/pubmed/22975303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fgb.2012.08.006
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