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Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans
Amino acid biosynthetic pathways that are absent in mammals are considered an attractive target for antifungal therapy. Leucine biosynthesis is one such target pathway, consisting of a five-step conversion process starting from the valine precursor 2-keto-isovalerate. Isopropylmalate dehydrogenase (...
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| Publicat a: | Fungal Genet Biol |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4706550/ https://ncbi.nlm.nih.gov/pubmed/25554701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fgb.2014.12.006 |
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