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Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans

Amino acid biosynthetic pathways that are absent in mammals are considered an attractive target for antifungal therapy. Leucine biosynthesis is one such target pathway, consisting of a five-step conversion process starting from the valine precursor 2-keto-isovalerate. Isopropylmalate dehydrogenase (...

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Detalhes bibliográficos
Publicado no:Fungal Genet Biol
Main Authors: Do, Eunsoo, Hu, Guanggan, Caza, Mélissa, Oliveira, Debora, Kronstad, James W., Jung, Won Hee
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706550/
https://ncbi.nlm.nih.gov/pubmed/25554701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fgb.2014.12.006
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