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Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity

INTRODUCTION: The study of xenobiotic metabolism and toxicity has been greatly aided by the use of genetically-modified mouse models and metabolomics. AREAS COVERED: Gene knockout mice can be used to determine the enzymes responsible for the metabolism of xenobiotics in vivo and to examine the mecha...

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Detalhes bibliográficos
Publicado no:Expert Opin Drug Metab Toxicol
Main Authors: Gonzalez, Frank J., Fang, Zhong-Ze, Ma, Xiaochao
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706076/
https://ncbi.nlm.nih.gov/pubmed/25836352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425255.2015.1032245
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