IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1)

Toll-like receptors (TLR) and the receptor for interleukin-1 (IL-1R) signaling play an important role in bacteria-mediated bone loss diseases including periodontitis, rheumatoid arthritis, and osteomyelitis. Recent studies have shown that TLR ligands inhibit the receptor activator of NF-κB ligand (R...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chen, Zhihong, Su, Lingkai, Xu, Qingan, Katz, Jenny, Michalek, Suzanne M., Fan, Mingwen, Feng, Xu, Zhang, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706008/
https://ncbi.nlm.nih.gov/pubmed/26483549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663518
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