Systematic identification and annotation of human methylation marks based on bisulfite sequencing methylomes reveals distinct roles of cell type-specific hypomethylation in the regulation of cell identity genes

DNA methylation is a key epigenetic mark that is critical for gene regulation in multicellular eukaryotes. Although various human cell types may have the same genome, these cells have different methylomes. The systematic identification and characterization of methylation marks across cell types are...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Liu, Hongbo, Liu, Xiaojuan, Zhang, Shumei, Lv, Jie, Li, Song, Shang, Shipeng, Jia, Shanshan, Wei, Yanjun, Wang, Fang, Su, Jianzhong, Wu, Qiong, Zhang, Yan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Computational Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705665/
https://ncbi.nlm.nih.gov/pubmed/26635396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1332
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